The Science
SMSbiotech is developing cutting-edge adult stem cell technology that aims at providing safe, affordable, and ethically grounded regenerative medicine.
Introduction
SMSbiotech is developing cutting-edge adult stem cell technology that aims to provide safe, effective, affordable, and ethically grounded regenerative medicine.
Pioneering Regenerative Medicine
SMSbiotech has been at the forefront of developing cutting-edge adult stem cell technology dedicated to providing safe, effective, affordable, and ethically grounded regenerative medicine.
Patented Bio-Manufacturing Technology
Leveraging our patented technology (6 received, 10 pending), we bio-manufacture human Small Mobile Stem Cells and essential proteins derived from these cells, including matrisomal and other extracellular matrix proteins.
Industrial-Scale Production Capability
Through extensive development, we have established large, industrial-scale production capabilities for SMS cells and their byproducts, ensuring widespread availability for medical applications.
Proprietary SMS Cell
Techniques
Our proprietary techniques enable the isolation and indefinite growth of native adult SMS cells, laying the foundation for groundbreaking regenerative therapies.
Regenerative Potency and Cell Characteristics
As true stem cells, SMS cells exhibit strong interactions with key regenerative cells (Mesenchymal Stem Cells, Endothelial Cells, Alveolar Progenitor Cells, Chondrocytes, and Fibroblast), stimulating growth and triggering gene expression changes without transformation or manipulation.
Validating Bio-Manufacturing Quality
Novel in-vitro functional assay systems meticulously test SMS cell bio-manufacturing quality, guaranteeing in-vivo potency at both cellular and molecular levels. SMS cells have resilient properties that help maintain the quality of the cells.
Resilience and Therapeutic Opportunities
The remarkable physical and chemical resilience of SMS cells allows them to serve tissues and organs effectively even under stressful, diseased conditions, opening new avenues for drug administration, rational logistics, and simple storage (4°C for 3 weeks).
Inducement of Blood Vessels
SMS cells produce ample proteins known for their regenerative effects on human cells and tissues. The extracellular matrix derived from SMS cells demonstrates exceptional blood vessel inducement in-vitro and in-vivo. Large visible vessels can be formed in-vitro.
Therapeutic
Potential
Animal Model Studies
Rigorous studies utilizing animal models showcase the exceptional therapeutic potential of SMS cells, effectively regenerating damaged tissues in the skin and lungs.
Safety and Immunocompromised Testing
Extensive safety assessments, including large-scale administration to various tissues and animal species, confirm the absence of adverse effects and tumorigenicity as expected from adult stem cells.
Healing Processes and Tissue Regeneration
Essential Processes for Tissue Healing
Stimulation of parenchymal cells and progenitor stem cell proliferation, coupled with tissue vascularization and extracellular matrix production, forms the foundation for rapid and effective tissue healing in diverse organs.
Focus on COPD
Our in-vitro and in-vivo research highlights the potential of SMS cells for addressing Chronic Obstructive Pulmonary Disease (COPD), a severe, degenerative lung condition lacking effective treatment that affects +400 million people worldwide.
Advantages of SMSbiotech's Technology
High-Quality, Immuno-Tolerant Therapeutic Cells
Our technology grants patients access to high-quality, immuno-tolerant, and affordable human (allogeneic, off-the-shelf) therapeutic cells, expanding treatment options and addressing unmet needs that affect hundreds of millions worldwide.
Industrial-Scale Therapeutic Byproducts
Beyond cells, our technology yields critical therapeutic proteins at an industrial scale, facilitating in vivo tissue regeneration and in vitro tissue reconstruction.
Enabling Cost-Effective Medical Advances
SMSbiotech's robust technology paves the way for cost-effective methods in organ repair, tissue and vascular regeneration, and scaffold and tissue engineering.
Why SMS Cells Are Superior To Other Stem Cells
Extensive Proliferation with Retained Potency
SMS cells can proliferate extensively without losing functional potency, retaining their ability to differentiate into other cells, interact with key regenerative cells, and produce critical regenerative factors.
Proliferation and Safety Testing
SMS cells have been extensively proliferated and rigorously tested in vitro and in vivo, using multiple animal species, to demonstrate consistent safety and the absence of toxicity and tumorigenicity.
Genetic Stability
SMS cells are not genetically manipulated, further enhancing their safety profile compared to genetically engineered counterparts.
Origin from Adult Human Tissues
Unlike embryonic and genetically engineered cells, SMS cells are adult stem cells derived from adult human tissues. This characteristic ensures that transferring SMS cells to human tissue does not expose it to embryonic state cells, providing a safer option for cell therapy.
Return to "Natural Habitat"
SMS cells are isolated from regular blood and return to their natural habitat when injected into the bloodstream. This characteristic distinguishes them from adult Mesenchymal Stem cells, offering unique advantages.
Stimulation of Mesenchymal Stem Cell Proliferation
SMS cells stimulate mesenchymal stem cell proliferation, potentially inducing beneficial regenerative effects of MSCs endogenously.
Multi-Cell Targeting
Unlike Mesenchymal stem cells that primarily target immune cells, SMS cells target multiple different cells that have direct significance to tissue regeneration.
Limited Histocompatibility Proteins
SMS cells possess very few to no histocompatibility proteins, reducing the likelihood of inducing significant immune reactions, in contrast to MSCs.
Avoidance of Capillary Clogging
The smaller size of SMS cells reduces the risk of clogging capillaries and getting stuck in the lungs, which can be a concern with Mesenchymal cells.
Sturdiness and Robustness
SMS cells are sturdier and more robust, providing practical benefits in their handling and application.